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August 26, 2025Advanced ScienceOpen Access

Hepatocyte‐Specific GSDMD Deficiency Aggravates Sepsis by Disrupting Non‐Canonical Secretion of Anti‐Inflammatory Factors

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Authors

YQYihan QianBWBingrui WangCYChang Yu

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Overview

Hepatocyte-specific knockout worsens inflammation in sepsis, indicating GSDMD's role in anti-inflammatory factor secretion.

Key Points

  • Absence of GSDMD in hepatocytes worsens sepsis outcomes, increasing inflammation and mortality rates.
  • GSDMD hep-/- mice had significantly reduced survival rates and elevated systemic inflammation levels.
  • Experiments confirm that GSDMD facilitates the release of anti-inflammatory factors like VEGF-B and Gremlin-1.
  • Replenishing GSDMD in hepatocytes reverses heightened inflammatory responses, showing its protective role in sepsis.

Cite This Study

Qian et al. (2025) studied this question.

synapsesocial.com/papers/68af7dec7567bf4f94ff4acbhttps://doi.org/10.1002/advs.202510412
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1GSDMD ablation reduces intestinal inflammation of experimental NEC through macrophage pyroptosis2025
  2. 2Phosphoglycerate dehydrogenase interacts with and inhibits the protein kinase TAK1 to mitigate septic shock2025
  3. 3Pan-membrane pyroptosis of liver induced by gasdermin-encoding mRNAs2025 · 3 citations
  4. 4GSDMD deficiency attenuates BPD by suppressing macrophage pyroptosis and promoting M2 polarization2025
  5. 5Disulfiram Protects Against Multiorgan Injuries and Cell Pyroptosis via Inhibiting <scp>GSDMD</scp> in Severe Acute Pancreatitis Mice2025