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September 10, 2025Journal of Biological ChemistryOpen Access

Phosphoglycerate dehydrogenase interacts with and inhibits the protein kinase TAK1 to mitigate septic shock

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Authors

PHPenghui HuZJZemin JiHXHui Xiong

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Overview

Analysis reveals phosphoglycerate dehydrogenase inhibits TAK1 in macrophages, suggesting new sepsis therapies.

Key Points

  • Phosphoglycerate dehydrogenase reduces inflammation in sepsis, mitigating organ damage during septic shock.
  • Knockdown of PHGDH leads to enhanced inflammatory responses to LPS and E. coli, increasing risk in septic models.
  • Mechanistic studies show PHGDH inhibits TAK1 binding, thereby suppressing the TAK1-NF-κB/MAPK signaling pathway.
  • AAV-mediated PHGDH overexpression in macrophages significantly decreases sepsis-related inflammation and damage.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68c2443bb210217d647a9e95https://doi.org/10.1016/j.jbc.2025.110658
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