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July 24, 2025

GSDMD ablation reduces intestinal inflammation of experimental NEC through macrophage pyroptosis

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Authors

CYCuilian YeChongqing University of TechnologyXLXinli LiuChongqing Maternal and Child Health HospitalYMYue MaVan Andel Institute

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Implication

Experimental models reveal GSDMD's role in macrophage pyroptosis and inflammation in necrotizing enterocolitis, suggesting therapeutic potential.

Key Points

  • GSDMD ablation significantly reduces intestinal inflammation in mice with NEC, indicating its crucial role.
  • Correlation established between GSDMD and macrophage pyroptosis in infants with NEC, highlighting a potential target.
  • GSDMD-deficient models demonstrated improved NEC symptoms and lower intestinal macrophage presence, showing its importance.
  • GSDMD inhibition enhances macrophage antibacterial abilities without affecting their phagocytic behavior, underscoring its functional nuances.

Cite This Study

Ye et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8cdf51https://doi.org/10.21203/rs.3.rs-6983696/v1
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