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October 23, 2025National Science ReviewOpen Access

Pan-membrane pyroptosis of liver induced by gasdermin-encoding mRNAs

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Authors

YHYi-Jiao HuangLLLi LinGYGuan Yang

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Overview

In vivo pyroptosis induces acute liver damage and systemic inflammation, suggesting potential GSDM-targeted therapeutics.

Key Points

  • Pyroptosis leads to acute liver damage and systemic inflammation due to GSDMDNT expression.
  • Robust expression of GSDMDNT via lipid-nanoparticle injections results in serious effects in mice and primates.
  • Observational analysis shows disulfiram and glucocorticoids can reverse the effects of pyroptosis-induced damage.
  • These findings highlight the potential for developing therapeutics targeting gasdermins in pyroptotic conditions.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68fa1210f9f8b44535bfccc3https://doi.org/10.1093/nsr/nwaf452
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