What question did this study set out to answer?

This research aims to determine the role of GSDMD-mediated macrophage pyroptosis in bronchopulmonary dysplasia (BPD).

December 8, 2025Cell Death DiscoveryOpen Access

GSDMD deficiency attenuates BPD by suppressing macrophage pyroptosis and promoting M2 polarization

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Inhibition of GSDMD improves vascular development and reduces IL-1β in hyperoxia-induced BPD, suggesting potential therapies.

This research aims to determine the role of GSDMD-mediated macrophage pyroptosis in bronchopulmonary dysplasia (BPD).
Used neonatal C57BL/6 wild-type and GSDMD-knockout mice to create a hyperoxia-induced BPD model.
Administered disulfiram, a GSDMD inhibitor, to assess its impact on BPD.
Evaluated lung histopathology, IL-1β levels, and alveolarization.
Isolated bone-marrow-derived macrophages to assess pyroptotic markers and M1/M2 polarization.
GSDMD deletion and disulfiram treatment reduced macrophage and neutrophil infiltration in the lungs.
Lowered pulmonary IL-1β concentrations and improved alveolar architecture and vascular density.
BMDMs from GSDMD −/− mice showed decreased M1 polarization and enhanced bacterial killing capabilities.

Wang et al. (2025) studied this question.

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