January 1, 2025

Single-Cell RNA Sequencing Reveals Pericytes Acquire a Fibrotic Phenotype and Promote Mesenteric Adipose Tissue Fibrosis in Crohn's Disease.

View Full Paper

Ask AI

Bookmark

Authors

Discussion

This analysis reveals that pericytes enhance fibrosis in mesenteric adipose tissue of Crohn's disease, suggesting potential therapeutic targets.

Pericytes transition to a fibrotic phenotype, contributing to mesenteric adipose tissue fibrosis in Crohn's disease.
Core extracellular matrix gene COL3A1 was significantly upregulated in both Crohn's disease-associated and creeping fat tissues.
Single-cell RNA sequencing mapped pericyte differentiation and profibrotic gene expression after stimulation with transforming growth factor-β1.
Findings highlight a novel cellular mechanism driving fibrosis, potentially guiding future therapeutic strategies for mesenteric adipose tissue fibrosis.

Zhang et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

This analysis reveals that pericytes enhance fibrosis in mesenteric adipose tissue of Crohn's disease, suggesting potential therapeutic targets.