October 10, 2025Circulation Research

Abstract Thu144: Prolonged Cardiac Fibroblast Conditioning on Soft Matrix Maintains Quiescence but Permits Agonist-Mediated Myofibroblast Activation

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Prolonged exposure to soft substrates keeps cardiac fibroblasts in a quiescent state while allowing activation by myofibroblast agonists.
When replated on soft matrix, fibroblasts lose a-smooth muscle actin expression, indicating a shift from activation to quiescence.
Experimental data suggest that softer matrices enhance the transcriptional accessibility for myofibroblast activation through an epigenetic mechanism.
Understanding fibroblast behavior in varying matrix stiffness could provide insights for developing better in vitro models for cardiac health.

Authors

CBCarrie BishopUniversity of California, San Diego HAHamza AtchaUniversity of North Carolina at Chapel Hill ZWZhaoning WangColumbia University Irving Medical Center

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Implication

Observational analysis reveals soft matrices maintain cardiac fibroblast quiescence while allowing myofibroblast activation, suggesting epigenetic regulation.

Cite This Study

Bishop et al. (2025) studied this question.

synapsesocial.com/papers/68e861a57ef2f04ca37e47be https://doi.org/10.1161/res.137.suppl_1.thu144

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Implication

Observational analysis reveals soft matrices maintain cardiac fibroblast quiescence while allowing myofibroblast activation, suggesting epigenetic regulation.

Abstract Thu144: Prolonged Cardiac Fibroblast Conditioning on Soft Matrix Maintains Quiescence but Permits Agonist-Mediated Myofibroblast Activation

Key Points

Discussion

Implication

Cite This Study

Abstract Thu144: Prolonged Cardiac Fibroblast Conditioning on Soft Matrix Maintains Quiescence but Permits Agonist-Mediated Myofibroblast Activation

Key Points

Discussion

Implication

Cite This Study

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