July 14, 2025Open Access

B cell/adipocyte crosstalk drives pro-fibrotic macrophage migration and polarisation in Crohn`s disease-associated, inflamed adipose tissue

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B cell and pro-fibrotic macrophage accumulation occurs in crohn's disease-associated adipose tissue.
Depleting b cells in a mouse model significantly reduces pro-fibrotic macrophage accumulation.
B cell/adipocyte co-cultures lead to elevated MCP-1 secretion, enhancing macrophage migration.
The study highlights the role of lactate-rich environments in supporting inflammation and macrophage polarization.

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Implication

Research reveals how b cell and adipocyte interactions drive inflammation and macrophage polarization in crohn's disease, indicating a pathway for therapeutic intervention.

Cite This Study

Goess et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc3e3 https://doi.org/10.1101/2025.07.11.664132

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Implication

Research reveals how b cell and adipocyte interactions drive inflammation and macrophage polarization in crohn's disease, indicating a pathway for therapeutic intervention.

B cell/adipocyte crosstalk drives pro-fibrotic macrophage migration and polarisation in Crohn`s disease-associated, inflamed adipose tissue

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Discussion

Implication

Cite This Study

B cell/adipocyte crosstalk drives pro-fibrotic macrophage migration and polarisation in Crohn`s disease-associated, inflamed adipose tissue

Key Points

Discussion

Implication

Cite This Study

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