September 11, 2025AJP Cell PhysiologyOpen Access

Pro-Fibrotic Immune Cells and Fibro-Adipogenic Progenitors Contribute to Skeletal Muscle Extracellular Matrix Remodeling and Fibrosis in Cancer Cachexia

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Cachectic mice exhibited significant muscle mass loss and increased fibrosis compared to controls, indicating muscle deterioration.
Changes in immune cell populations, particularly profibrotic macrophages and fibro-adipogenic progenitors, were prevalent in cachectic muscle.
Analysis utilizing flow cytometry, scanning electron microscopy, and transmission electron microscopy highlighted ECM abnormalities in cachectic mice.
Targeting profibrotic immune cells may mitigate the adverse effects of cancer cachexia on skeletal muscle function.

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Observational analysis shows increased immune cells and fibro-adipogenic progenitors in cachectic mice, suggesting their role in muscle fibrosis.

Cardaci et al. (2025) studied this question.

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Observational analysis shows increased immune cells and fibro-adipogenic progenitors in cachectic mice, suggesting their role in muscle fibrosis.