August 21, 2025Open Access

The Role of the Senescence-Associated Secretory Phenotype in Cardiovascular Disease Among the Elderly

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Discussion

This review highlights SASP's impact on inflammation and vascular aging in older adults, suggesting senolytics may mitigate age-related CVD.

SASP contributes to systemic inflammation and myocardial fibrosis, worsening cardiovascular disease in older adults.
Key features include arterial stiffness and plaque instability, which are crucial in age-related cardiovascular conditions.
This review synthesizes evidence from various studies on SASP's role in vascular aging and heart failure among the elderly population.
Emerging therapies like senolytics could potentially reduce the adverse effects of SASP on cardiovascular health among older adults.

Sutanto et al. (2025) studied this question.

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This review highlights SASP's impact on inflammation and vascular aging in older adults, suggesting senolytics may mitigate age-related CVD.