July 21, 2025Open Access

Metabolically Active but Dysfunctional: The Role of Senescence and SASP in Metabolic Diseases

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Discussion

Review highlights how senescence and SASP contribute to insulin resistance in metabolic diseases, suggesting potential therapies.

Accumulation of senescent cells in metabolic tissues significantly contributes to chronic inflammation and dysfunction.
Senescence-associated secretory phenotype (SASP) secretes pro-inflammatory signals that disrupt metabolic processes.
Emerging therapies like senolytics aim to clear senescent cells and mitigate their inflammatory effects on metabolism.
Understanding the molecular mechanisms of senescence is crucial for developing strategies against age-related metabolic disorders.

Viniak et al. (2025) studied this question.

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