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November 8, 2025Open Access

Endothelial dysfunction and vascular stiffness: molecular drivers of cardiovascular aging

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Authors

MÇMuhammet Cihat ÇelikMKMacit KalçıkABAbdülmelik Bi̇rgün

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Overview

Findings reveal endothelial dysfunction and vascular stiffness as predictors of cardiovascular events, highlighting key molecular pathways and interventions.

Key Points

  • Progressive endothelial dysfunction elevates the risk of hypertension and heart failure with aging.
  • Analysis demonstrates that interplay among NADPH oxidases, nitric oxide, and inflammation drives vascular aging.
  • Assessment using biomarkers indicates the significance of endothelial dysfunction and vascular stiffness in cardiovascular health.
  • Understanding molecular regulators offers new avenues in targeting vascular aging and enhancing heart health.

Cite This Study

Çelik et al. (2025) studied this question.

synapsesocial.com/papers/690e8b6ca5b062d7a4e73573https://doi.org/10.37349/ec.2025.101279
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