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September 18, 2025Circulation Research

Dysregulated Protein s -Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure With Preserved Ejection Fraction

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Authors

ZLZhen LiKLKyle B. LaPennaNGNatalie Gehred

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Overview

Observational analysis finds elevated s-nitrosylation in heart failure with preserved ejection fraction, indicating nitrosative stress may drive disease progression.

Key Points

  • Elevated levels of s-nitrosothiols in patients with HFpEF indicate increased nitrosative stress.
  • Transcriptomic analysis revealed upregulation of transnitrosylase HBb in rat and human HFpEF hearts.
  • Cell-based experiments showed that altered expression of HBb and Trx2 led to higher cellular RxNO.
  • Dysregulation of s-nitrosylation was also observed in peripheral organs like kidneys and livers in HFpEF.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d434d6713b0b5dfea73dfahttps://doi.org/10.1161/circresaha.124.326042
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric oxide‑mediated S‑Nitrosylation contributes to signaling transduction in human physiological and pathological status (Review)2025
  2. 2Decreased Endogenous Nitric Oxide Production in Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction2025 · 2 citations
  3. 3Abstract Wed078: Post-transcriptional Regulation of Adrenal-Heart Crosstalk in Heart Failure with Preserved Ejection Fraction2025
  4. 4Abstract Wed091: Biomechanical and Transcriptomic Remodeling of the Heart in Heart Failure with Preserved Ejection Fraction2025
  5. 5The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming2025