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December 19, 2025Deleted JournalOpen Access

DNA methylation landscapes in human cells and their chromatin determinants

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Authors

WCWei CuiZHZhijun HuangGPGerd P. Pfeifer

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Overview

Research demonstrates DNA methylation patterns in human cells, highlighting aging and cancer implications.

Key Points

  • To explore the DNA methylation patterns and chromatin determinants in human cells, focusing on cancer and aging.
  • Used whole genome bisulfite sequencing to profile DNA methylation at single base resolution.
  • Conducted chromatin-immunoprecipitation sequencing to analyze various histone modifications in human bronchial epithelial cells.
  • Investigated the relationship between different histone marks and DNA methylation patterns.
  • Found that lower DNA methylation regions are associated with Polycomb repressive complex 2 marks, particularly H3K27 trimethylation.
  • Noted less association of PRC1 mark and depletion of H3K36 di- and tri-methylation in these regions.
  • Identified distinct relationships between DNA methylation and histone modifications in methylated CpG islands versus non-CpG island regions.

Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/69449a922f0218eca95086a4https://doi.org/10.70401/acrt.2025.0007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epigenetic relay: Polycomb-directed DNA methylation in mammalian development2025 · 5 citations
  2. 2Epigenetic markers of middle-age: non-linear DNA methylation changes with aging in humans2025 · 1 citations
  3. 3DNA Methylation Ageing Atlas Across 17 Human Tissues2025 · 12 citations
  4. 4DNA Methylation Ageing Atlas Across 17 Human Tissues2025 · 3 citations
  5. 5The genetic basis for DNA methylation variation across tissues and development2026 · 1 citations