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August 16, 2025Open Access

Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for functional differentiation of Treg cells

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Authors

RMRyuichi MurakamiNHNorihito HayatsuTMTakahisa Miyao

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Overview

Analysis reveals Foxp3 and BATF direct cis-regulatory programs in Treg cells, suggesting new insights into transcription factors.

Key Points

  • Foxp3 and BATF cooperate to enhance gene expression and cis-regulatory programs in Treg cells, facilitating differentiation.
  • Key evidence shows simultaneous single-cell profiling revealed joint regulation of cis-regulatory elements by both factors.
  • Analysis employed genome-wide mapping to identify specific binding sites for Foxp3 and BATF in eTreg cells.
  • These findings suggest that understanding Foxp3's role as a master regulator may lead to new strategies for Treg cell differentiation.

Cite This Study

Murakami et al. (2025) studied this question.

synapsesocial.com/papers/68af70687567bf4f94feba37https://doi.org/10.1101/2025.08.13.669552
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The New Insight Into the Role of Transcription Factors in the Function of Regulatory T Cells With Emphasis on FOXP3 and Its Implication in the Treatment of Autoimmune Disorders2026
  2. 2The transcription factor BATF pioneers the differentiation program of effector CD8+ T cells through the interaction with IRF42025 · 5 citations
  3. 3BATF DRIVES A TARGETABLE CONVERGENT GENE PROGRAM IN CROHN’S DISEASE ASSOCIATED CD4+ T CELLS2026
  4. 4Determining FoxP3’s role in hCD8+ iTreg generation, stability, phenotype and function 37312025
  5. 5Normal Treg homeostasis and suppressive function require both FOXP1 and FOXP42025 · 5 citations