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August 12, 2025JCI InsightOpen Access

Normal Treg homeostasis and suppressive function require both FOXP1 and FOXP4

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Authors

DDDachuan DongVSVishal SindhavaAGAnanthakrishnan Ganesan

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Overview

Loss of FOXP1 and FOXP4 in Tregs shows suppressed CD25 expression and cytokine production, implying critical regulatory roles.

Key Points

  • Mice lacking FOXP1 and FOXP4 exhibited significant lymphoproliferation and early lethality, with compromised immune tolerance.
  • Combined deficiency led to increased proinflammatory cytokine production and alterations in germinal center responses.
  • The study applied genetic deletion techniques to observe Treg behavior in mice, revealing non-redundant roles of FOXP family members.
  • Findings underscore the essential regulatory function of FOXP1 and FOXP4 in maintaining Treg homeostasis and suppressive capability.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/689fc948e46e096235ce15bbhttps://doi.org/10.1172/jci.insight.195981
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