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January 6, 2026Scandinavian Journal of Immunology

The New Insight Into the Role of Transcription Factors in the Function of Regulatory T Cells With Emphasis on FOXP3 and Its Implication in the Treatment of Autoimmune Disorders

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Authors

ASAfsaneh ShamsiMTMahdi TaghadosiFKFatemeh khoobbakht

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Overview

Review highlights transcription factors' roles in Treg cells, suggesting new therapeutic strategies for autoimmune diseases.

Key Points

  • This review examines the role of transcription factors in regulatory T cell functions and their implications in autoimmune disorders.
  • Literature review on transcription factors and regulatory T cells
  • Analysis of immune tolerance mechanisms
  • Examination of FOXP3 and accessory transcription factors
  • Regulatory T cells are vital for maintaining immune tolerance
  • FOXP3 is a key transcription factor for Treg cell programming
  • Disruption in Treg cell functions is linked to autoimmune diseases
  • New therapeutic strategies for autoimmune disorders are suggested based on transcription factors' roles

Cite This Study

Shamsi et al. (2026) studied this question.

synapsesocial.com/papers/695d855e3483e917927a4c73https://doi.org/10.1111/sji.70086
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