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September 10, 2025Cell ReportsOpen Access

The transcription factor BATF pioneers the differentiation program of effector CD8+ T cells through the interaction with IRF4

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Authors

SFSotaro FujisawaYTYamato TanabeAHArisa Hojo

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Overview

Experimental analysis reveals BATF's critical role in CD8+ T cell effector differentiation, highlighting its interaction with IRF4.

Key Points

  • BATF plays a crucial role in the differentiation of effector CD8+ T cells during acute viral infection, promoting critical cellular functions.
  • The interaction between BATF and IRF4 is essential for effective chromatin remodeling and proliferation of antigen-specific CTLs.
  • BATF can initiate chromatin remodeling independently; however, a further dynamic epigenomic reorganization requires IRF4's involvement.
  • Loss of BATF severely disrupts gene expression and chromatin accessibility, impacting overall T cell responses.

Cite This Study

Fujisawa et al. (2025) studied this question.

synapsesocial.com/papers/68c241acb210217d647a0bdahttps://doi.org/10.1016/j.celrep.2025.116129
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1BATF DRIVES A TARGETABLE CONVERGENT GENE PROGRAM IN CROHN’S DISEASE ASSOCIATED CD4+ T CELLS2026
  2. 2Foxp3 and BATF cooperatively direct <i>cis</i>-regulatory programs and gene expression for functional differentiation of Treg cells2025
  3. 3Immunomodulatory Transcription Factor BATF2 regulates the Interferon Stimulated Genes Expression during Influenza A virus Infection2025
  4. 4Enhancing anti-tumor immunity by targeting BATF and the STAT1/PD-L1 pathway in cervical carcinoma2025 · 1 citations
  5. 5BATF2-Mediated Control of Astrocyte Proliferation2025