August 19, 2025Molecular PsychiatryOpen Access

Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies

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Authors

XSXueyi Shen YTYara J. Toenders LHLaura K. M. Han

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Implication

Mega-analysis shows higher polygenic risk scores for major depression correlate with lower brain volumes in participants, highlighting neurobiological implications.

Key Points

Higher polygenic risk scores for major depression correlate with reduced intracranial volume and cortical surface area, revealing a neurological basis for the disorder.
Analysis involved data from 50,975 participants across 11 studies, with significant findings related to frontal lobe surface area and subcortical region volumes.
Investigating the relationship between genetic risk and brain structure through rigorous neuroimaging protocols supported by large collaborative efforts.
Findings indicate potential causal links between smaller hippocampal volume and increased liability for major depression, emphasizing the need for early intervention.

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/68af35ddcf1dd9ea359e9bfe https://doi.org/10.1038/s41380-025-03136-4

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Implication

Mega-analysis shows higher polygenic risk scores for major depression correlate with lower brain volumes in participants, highlighting neurobiological implications.

Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies

Discussion

Member takes

Implication

Key Points

Cite This Study

Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies

Discussion

Member takes

Implication

Key Points

Cite This Study

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