September 25, 2025Open Access

Combined family history and polygenic score prediction of major depressive disorder

View Full Paper

Ask AI

Bookmark

Authors

RWRujia Wang HDHelena L. Davies SLSang Hyuck Lee

Discussion

Member takes

Overview

Analysis reveals combined family history and polygenic scores predict major depressive disorder in diverse populations, suggesting clinical applications.

Key Points

Family history and polygenic scores combined can explain 33% variance in major depressive disorder diagnosis across two cohorts.
In the GLAD+ cohort, family history explained 17% variance, and in UK Biobank it was 13%, with both showing strong predictive performance.
Using elastic net regression, the study identified key predictors including family history, childhood trauma, and sociodemographic factors.
This integrated model may enhance early diagnosis and personalized treatment strategies for individuals at high risk of major depressive disorder.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d5d0d7ddad3c16d4635eb6 https://doi.org/10.1101/2025.09.22.25336356

View Full Paper

Ask AI

Bookmark

September 25, 2025Open Access

Combined family history and polygenic score prediction of major depressive disorder

View Full Paper

Ask AI

Bookmark

Authors

RWRujia Wang HDHelena L. Davies SLSang Hyuck Lee

Discussion

Member takes

Overview

Analysis reveals combined family history and polygenic scores predict major depressive disorder in diverse populations, suggesting clinical applications.

Key Points

Family history and polygenic scores combined can explain 33% variance in major depressive disorder diagnosis across two cohorts.
In the GLAD+ cohort, family history explained 17% variance, and in UK Biobank it was 13%, with both showing strong predictive performance.
Using elastic net regression, the study identified key predictors including family history, childhood trauma, and sociodemographic factors.
This integrated model may enhance early diagnosis and personalized treatment strategies for individuals at high risk of major depressive disorder.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d5d0d7ddad3c16d4635eb6 https://doi.org/10.1101/2025.09.22.25336356

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark