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September 18, 2025Molecular PsychiatryOpen Access

Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up

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Authors

MHMarit HaramOslo University HospitalAJAndreas JangmoPJPiotr Pawel JaholkowskiOslo University Hospital

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Implication

Analysis reveals associations between polygenic risk scores and self-reported depression measures, highlighting variations by severity.

Key Points

  • Polygenic risk scores significantly predict depression severity across varied diagnostic thresholds.
  • Higher effect sizes were observed for severe depression, particularly in individuals with inpatient histories.
  • Linear and logistic models demonstrated robust associations between PRS and self-reported depression metrics.
  • Findings underline the importance of genetic risk in identifying those at risk for serious depression outcomes.

Cite This Study

Haram et al. (2025) studied this question.

synapsesocial.com/papers/68d433b8713b0b5dfea738c2https://doi.org/10.1038/s41380-025-03243-2
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