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September 5, 2025CellsOpen Access

The Role of Tumor Microenvironment in Triple-Negative Breast Cancer and Its Therapeutic Targeting

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Authors

AVAna VuletićKMKatarina Mirjačić MartinovićVJVladimir Jurišić

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Overview

This review uncovers immune cell interactions in the tumor microenvironment of TNBC, suggesting new therapeutic targets.

Key Points

  • Therapies targeting the tumor microenvironment may enhance treatment for triple-negative breast cancer.
  • The immune cell interactions within the tumor microenvironment play a crucial role in cancer progression.
  • Cytokines and chemokines mediate the complex dynamics of immune cells and tumor cells in TNBC.
  • Cancer-associated fibroblasts contribute significantly to tumor invasion and may serve as critical therapeutic targets.

Cite This Study

Vuletić et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477e8d0https://doi.org/10.3390/cells14171353
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cytokine Networks in Triple-Negative Breast Cancer: Mechanisms, Therapeutic Targets, and Emerging Strategies2025
  2. 2Inflammation-associated drug resistance and tumor growth in TNBC2025 · 10 citations
  3. 3Immunotherapy resistance in triple-negative breast cancer: Molecular mechanisms, tumor microenvironment, and therapeutic implications2025 · 27 citations
  4. 4Integrating molecular targeting and immune modulation in triple-negative breast cancer: from mechanistic insights to therapeutic innovation2025 · 5 citations
  5. 5Therapeutic innovations in triple negative breast cancer: integrating molecular targeting and monoclonal antibody strategies2025 · 5 citations