This review highlights the role of tumor-associated macrophages in triple-negative breast cancer progression, suggesting potential therapeutic strategies.
Key Points
Tumor-associated macrophages significantly influence the development of triple-negative breast cancer through immunosuppressive mechanisms.
Cells in the M2-like phenotype facilitate cancer progression, including metastasis and angiogenesis, which complicate treatment options.
Current strategies involve targeting tumor-associated macrophages to enhance anti-tumor responses, potentially reprogramming them to an M1-like state.
Emerging therapies aim to improve clinical outcomes by exploiting the tumor microenvironment and blocking immune evasion pathways.