This minireview highlights how the tumor microenvironment influences tumor progression and therapy resistance in breast cancer, suggesting new therapeutic targets.
Key Points
The tumor microenvironment plays a critical role in breast cancer progression and therapy resistance.
Cancer-associated fibroblasts remodel the extracellular matrix and secrete growth factors that aid tumor growth.
Immune cells contribute to an immunosuppressive environment, hindering effective anti-tumor responses.
Understanding these interactions could lead to novel therapies aimed at reprogramming the tumor microenvironment.