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August 10, 2025BiomedicinesOpen Access

Genistein and Curcumin Inhibit Proliferation and Invasiveness in BRAFV600E Mutant and Wild-Type Melanoma Cells: Insights into Their Anticancer Effects

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Authors

FVFederico VaccaroFMFederica ManninoMSMariacarmela Santarpia

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Overview

Observational analysis revealed genistein and curcumin reduce invasiveness in melanoma cells, indicating potential therapeutic benefits.

Key Points

  • Genistein and curcumin significantly reduced proliferation and invasiveness in melanoma cells, highlighting their potential as therapeutic agents.
  • MTT assay demonstrated marked cell death and apoptosis induction, with DNA fragmentation confirming the effectiveness of both agents.
  • Assessment using cultured human melanoma cell lines revealed that genistein and curcumin both inhibit cell adhesion, suggesting reduced metastasis.
  • These findings support the potential use of nutraceuticals like genistein and curcumin in improving anticancer treatment regimens.

Cite This Study

Vaccaro et al. (2025) studied this question.

synapsesocial.com/papers/68af2695cf1dd9ea359e2441https://doi.org/10.3390/biomedicines13081954
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  1. 1Quercetin Modulates the p53 Signaling Pathway to Induce Apoptosis: Combating Vemurafenib Resistance in Melanoma2025 · 1 citations
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  3. 3Antitumor and Immunoregulatory Effects of Curcumin Analog, (Z)-3-Hydroxy-1-(2-hydroxyphenyl)-3-phenyl prop-2-ene-1-one (DK1), on CT26-Tumor-Bearing BALB/c Mi2025
  4. 4In Silico Study of Compounds Identified in Curcuma aeruginosa Roxb Rhizome as BRAF V600E Inhibitors in Melanoma Cancer2025
  5. 5Curcumin triggers reactive oxygen species-mediated apoptosis and suppresses tumor growth in metastatic oral squamous cell carcinoma2025