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September 23, 2025Midwestern Journal of Undergraduate SciencesOpen Access

The Pro-Apoptotic Effects of Curcumin on HCT116 Colorectal Cancer Cells

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Authors

KKKuljeet KaurSTSonia ThomasMDMelissa A. F. Daggett

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Overview

This research investigates curcumin and 5-Fluorouracil's effects on HCT116 colorectal cancer cells, suggesting alternative treatments.

Key Points

  • Curcumin demonstrated pro-apoptotic effects on HCT116 colorectal cancer cells, showing promise as a treatment alternative.
  • The study confirmed the effective concentration of curcumin, aiming to determine its LD50 compared to 5-FU.
  • MTT assays were used to assess cell viability at various curcumin and 5-FU concentrations after 24 hours.
  • Finding effective natural compounds like curcumin may provide less toxic treatment options for colorectal cancer.

Cite This Study

Kaur et al. (2025) studied this question.

synapsesocial.com/papers/68d44092713b0b5dfea7f27fhttps://doi.org/10.17161/mjusc.v4i1.23972
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