October 12, 2025Frontiers in OncologyOpen Access

Curcumin triggers reactive oxygen species-mediated apoptosis and suppresses tumor growth in metastatic oral squamous cell carcinoma

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Observational analysis showed curcumin induces apoptosis and inhibits tumor growth in oral squamous cell carcinoma, suggesting therapeutic potential.

Curcumin triggered apoptosis and increased ROS production in both 2D and 3D cell cultures, leading to cell death.
In vivo xenograft mouse models showed that curcumin suppressed tumor growth by reducing tumor emboli and metastatic nodules.
Assessments in 2D and 3D cultures revealed curcumin's cytotoxic effects through flow cytometry and microscopy techniques.
These findings highlight curcumin's potential as an effective treatment option for metastatic oral squamous cell carcinoma.

RAMOS et al. (2025) studied this question.

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Observational analysis showed curcumin induces apoptosis and inhibits tumor growth in oral squamous cell carcinoma, suggesting therapeutic potential.