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September 10, 2025Journal of Clinical Pharmacy and TherapeuticsOpen Access

Quercetin Modulates the p53 Signaling Pathway to Induce Apoptosis: Combating Vemurafenib Resistance in Melanoma

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Authors

CHChing-Wen HuangGCGong-Yau ChuCHChieh-Chen Huang

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Overview

Research shows quercetin reduces cell viability and induces apoptosis in vemurafenib-resistant melanoma, suggesting a potential therapeutic approach.

Key Points

  • Quercetin effectively reduces cell viability and induces apoptosis in vemurafenib-resistant melanoma cells.
  • Significant reductions in cell viability were observed, with an increase in apoptotic cell numbers and caspase activity.
  • RNA sequencing identified 379 differentially expressed genes and significant involvement of the p53 signaling pathway.
  • These findings suggest quercetin may serve as a promising strategy for overcoming drug resistance in melanoma.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c241acb210217d647a03a6https://doi.org/10.1155/jcpt/2635281
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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genistein and Curcumin Inhibit Proliferation and Invasiveness in BRAFV600E Mutant and Wild-Type Melanoma Cells: Insights into Their Anticancer Effects2025 · 1 citations
  2. 2Design, Synthesis, and Bioactivity Assessment of Modified Vemurafenib Analog2025
  3. 3The Combination of Casticin and Vemurafenib Enhances Apoptotic Cell Death Through the Mitochondria‐ and Caspases‐Mediated Pathways in Human Melanoma A375.S2 Cells In Vitro2025
  4. 4Phenotype switching in highly invasive resistant to vemurafenib and cobimetinib melanoma cells2025 · 5 citations
  5. 5Quercetin Increases Expression of Membrane-TRAIL in Glioblastoma Cells Resulting in Apoptosis2025