Antitumor and Immunoregulatory Effects of Curcumin Analog, (Z)-3-Hydroxy-1-(2-hydroxyphenyl)-3-phenyl prop-2-ene-1-one (DK1), on CT26-Tumor-Bearing BALB/c Mi
Antitumor effects of curcumin analog DK1 reduce tumor growth and regulate inflammation in colon cancer models, indicating its potential as an immunomodulatory agent.
Key Points
DK1 treatment reduced tumor volume and increased apoptotic tumor cells in colon cancer.
IL-1β expression was decreased significantly, alongside observed changes in immunophenotyping.
In vivo analysis utilized BALB/c mice that were induced to develop colon cancer for treatment assessment.
Findings may support DK1 as a promising candidate for future immunomodulatory therapies against cancer.