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August 1, 2025Infection and Drug ResistanceOpen Access

Emergence, Molecular Characteristics and Resistance Mechanisms of Colistin-Resistant Enterobacterales in Xuzhou, China

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Authors

SZShulong ZhaoXLXinyi LiangHLHuihui Li

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Overview

This research demonstrates colistin resistance mechanisms in Enterobacterales strains, indicating a widespread public health concern.

Key Points

  • Colistin resistance is associated with mutations in the mgrB gene and the mcr-1 gene.
  • In 14 resistant Klebsiella pneumoniae strains, mgrB mutations led to colistin resistance, while mcr-1 was found in E. coli strains.
  • Analysis involved methods like whole-genome sequencing and pulsed-field gel electrophoresis to confirm resistance mechanisms.
  • These findings highlight the urgent need for public health interventions to control the spread of resistant strains.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68af2690cf1dd9ea359e2180https://doi.org/10.2147/idr.s526613
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular characterization of colistin resistance in carbapenem-resistant <i>Klebsiella pneumoniae</i> from a tertiary hospital in China2025
  2. 2Evaluation of Colistin Susceptibility among Multidrug-Resistant Gram- Negative Pathogens isolated from Blood Culture: Evidence from a Tertiary Care Setting in Delhi, India2025
  3. 3Surveillance and characterization of carbapenem-resistant Enterobacter cloacae complex from China, 2015–20182025
  4. 4Co-occurrence of mcr-1 and mcr-3 mobilized colistin resistance genes among carbapenem-resistant Pseudomonas aeruginosa in Iran2025
  5. 5Epidemiology, Genetic Dynamics, and Transmission of the <i>mcr-1</i> Gene in China2025