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September 10, 2025Microbiology SpectrumOpen Access

Molecular characterization of colistin resistance in carbapenem-resistant Klebsiella pneumoniae from a tertiary hospital in China

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Authors

SQShu‐Yun QiHLHaijun LiJMJilei Ma

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Overview

Investigation reveals mgrB disruption as primary resistance mechanism in CRKP isolates, suggesting alternative pressures.

Key Points

  • Disruption of the mgrB gene is the main mechanism behind colistin resistance in ST11 CRKP isolates.
  • Among 134 K. pneumoniae isolates, colistin resistance was found in 48.5% of patients with no prior colistin exposure.
  • Whole-genome sequencing helped identify resistance mechanisms, including mutations and the presence of mcr genes.
  • The low prevalence of mcr genes and unexplained resistance highlights the need for improved antimicrobial stewardship.

Cite This Study

Qi et al. (2025) studied this question.

synapsesocial.com/papers/68c24364b210217d647a764ehttps://doi.org/10.1128/spectrum.01049-25
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