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October 11, 2025BMC Cardiovascular DisordersOpen Access

The combined prognostic effect of the triglyceride-glucose index and estimated glucose disposal rate on long-term mortality among individuals with cardiovascular-kidney-metabolic syndrome stages 0–3

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Authors

KWKexin WangWWWenjie WangJNJialong Niu

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Overview

Analysis shows the triglyceride-glucose index and estimated glucose disposal rate predict mortality, indicating important clinical implications for individuals with cardiovascular-kidney metabolic syndrome.

Key Points

  • TyG index and eGDR significantly predicted all-cause mortality rates of 14.9% in certain patient groups, emphasizing the need for integrative assessment.
  • Cox proportional regression revealed a hazard ratio of 3.338 for the TyG index and eGDR combination, highlighting their predictive capabilities for mortality.
  • The median follow-up time was 104 days, during which 1,079 all-cause deaths were recorded among participants with cardiovascular-kidney metabolic syndrome.
  • Modeling using restricted cubic splines displayed J-shaped and L-shaped associations for TyG index and eGDR with mortality, indicating complex relationships.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68ea72339f1bd4df558ced02https://doi.org/10.1186/s12872-025-05161-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Estimated Glucose Disposal Rate and Mortality in Cardiovascular Kidney Metabolic Syndrome: Nonlinear Associations and Stratified Prognostic Significance by Glycometabolic Phenotypes2025
  2. 2Association Between the Triglyceride-Glucose Index and All-Cause Mortality Among Patients with Diabetes and Chronic Kidney Disease: A Retrospective Cohort Study2025
  3. 3Comparison of triglyceride-glucose index and triglyceride-glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study2025
  4. 4The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism statuses2025 · 11 citations
  5. 5Association between the triglyceride-glucose index and major adverse cardiovascular events in patients with chronic kidney disease stages 3–42025 · 7 citations