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December 2, 2025BMJ Open OphthalmologyOpen Access

Associations between estimated glucose disposal rate and age-related ocular diseases in cardiovascular-kidney-metabolic syndrome stages 0–3: a large prospective cohort study

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Authors

LJLinge JianZHZhiqian Huang

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Overview

Prospective cohort analysis reveals glucose disposal rate is linked to ocular disease risk, suggesting implications for screening strategies in at-risk groups.

Key Points

  • Lower glucose disposal rate is associated with increased risk of glaucoma and macular degeneration in CKM syndrome, highlighting important clinical connections.
  • Macular degeneration showed a hazard ratio of 0.92 while glaucoma had a hazard ratio of 0.91, indicating strong links to insulin resistance.
  • Analysis utilized Cox proportional hazards models to evaluate outcomes of ocular diseases among 223,120 participants in the UK Biobank.
  • Findings support the potential for glucose disposal rate to inform ophthalmic screening practices in patients with cardiovascular-kidney-metabolic syndrome. 

Cite This Study

Jian et al. (2025) studied this question.

synapsesocial.com/papers/692e3d8d6c9b3ab28c187704https://doi.org/10.1136/bmjophth-2025-002465
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Accessing the relationship between estimated glucose disposal rate and the incidence of the kidney disease: results from the China Health and Retirement Longitudinal Study2025
  2. 2Insulin resistance assessed by estimated glucose disposal rate predicts cardiovascular disease in stages 0–3 of cardiovascular-kidney-metabolic syndrome: a UK biobank cohort study2025
  3. 3Estimated Glucose Disposal Rate and Mortality in Cardiovascular Kidney Metabolic Syndrome: Nonlinear Associations and Stratified Prognostic Significance by Glycometabolic Phenotypes2025
  4. 4Changes in the estimated glucose disposal rate and incident cardiovascular disease in patients with cardiovascular–kidney–metabolic syndrome stages 0–3: a prospective cohort study in China2025
  5. 5Changes in the Estimated Glucose Disposal Rate and Incident Cardiovascular Disease in Patients with Cardiovascular–Kidney–Metabolic Syndrome Stages 0–3: A Prospective Cohort Study in China2025