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August 7, 2025Cell Death and DiseaseOpen Access

ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer

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Authors

XXXiaozhou XieYZYulong ZhaoJLJin Liu

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Overview

Analysis identifies ZC3H13's role in regulating SNTB1 and facilitating EMT in gastric cancer, highlighting its prognostic impact.

Key Points

  • ZC3H13 is significantly upregulated in gastric cancer, contributing to patient poor prognosis.
  • The study uncovers ZC3H13's role in promoting proliferation, invasion, and migration of GC cells.
  • Mechanistically, ZC3H13 mediates YTHDF1-dependent m6A modification of SNTB1, leading to EMT activation.
  • Findings suggest that targeting ZC3H13 could be a new therapeutic approach for managing gastric cancer.

Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/689dfea6d61984b91e13c71ehttps://doi.org/10.1038/s41419-025-07889-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of ZC3H13 in promoting M2 macrophage infiltration via m6A methylation in esophageal squamous cell carcinoma tumor progression2025
  2. 2N(6)-methyladenosine modification of ADGRA3 by ZC3H13 suppresses papillary thyroid cancer cell malignancy by inactivating the PI3K/Akt/mTOR signaling pathway2025
  3. 3Clinical and prognostic significance of m6A hypomethylation and IGF2BP3 overexpression in gastric cancer: an integrated epigenomic-transcriptomic analysis2025
  4. 4ELK1 modulates SF3B3 transcriptional activity to stimulate proliferation and inhibit apoptosis in gastric cancer through the activation of the MAPK pathway2025
  5. 5Heterogeneous Nuclear Ribonucleoprotein A/B Drives Gastric Cancer and EMT via Akt-GSK3β-Wnt Pathway2025