Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
September 5, 2025Frontiers in ImmunologyOpen Access

The role of ZC3H13 in promoting M2 macrophage infiltration via m6A methylation in esophageal squamous cell carcinoma tumor progression

View Full Paper
Ask AI
Bookmark
Share

Authors

QYQihang YanCXChendi XuLGL. Gong

Discussion

Loading...

Member takes

Overview

Bioinformatics reveals ZC3H13's role in m6A methylation and M2 macrophages, suggesting key tumor microenvironment interactions.

Key Points

  • ZC3H13 promotes M2 macrophage infiltration, enhancing tumor progression in esophageal squamous cell carcinoma.
  • Silencing ZC3H13 inhibited tumor growth and M2 macrophage presence, indicating its crucial role in the tumor microenvironment.
  • M6A methylation modification stabilizes CXCL8 mRNA, thereby facilitating M2 macrophage polarization in esophageal tumors.
  • The study underscores the CXCL8-CXCR2 axis as significant for M0-M2 macrophage transition in the tumor microenvironment.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477c63chttps://doi.org/10.3389/fimmu.2025.1612041
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer2025
  2. 2METTL3-mediated m6A modification of ZIC2 promotes osteosarcoma development2025
  3. 3Multi-omics Approaches to CCAAT/Enhancer-Binding Protein Beta in Oral Squamous Cell Carcinoma: Crosstalk Between Tumor Cells and Tumor-Associated Macrophages Driving Disease Progression2025
  4. 4387. RNA M6A METHYLATION PROMOTES TUMOR DEVELOPMENT AND WASF3 TRANSLATION IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA2025
  5. 5<scp>ZBP1</scp> , an <scp>M1</scp> Macrophage‐Associated Biomarker Identified by Machine Learning, Suppresses Tumorigenesis and Predicts Immunotherapy Response in Head and Neck Squamous Cell Carcinoma2025