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September 5, 2025Discover OncologyOpen Access

N(6)-methyladenosine modification of ADGRA3 by ZC3H13 suppresses papillary thyroid cancer cell malignancy by inactivating the PI3K/Akt/mTOR signaling pathway

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Authors

CLCai LiLZLinghui ZhangZYZhaodan Yan

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Overview

Observational analysis reveals m6A modification of ADGRA3 suppresses papillary thyroid cancer cell malignancy, indicating a therapeutic target.

Key Points

  • Overexpression of ADGRA3 limits the proliferation, migration, and invasion of papillary thyroid cancer cells by inhibiting the PI3K/Akt/mTOR pathway.
  • Key metrics showed that ZC3H13 enhances ADGRA3 mRNA stability, which was confirmed through multiple assays like quantitative PCR and Western blotting.
  • This investigation employed cell functional assays, including the wound-healing and Transwell assays, to evaluate the malignancy of papillary thyroid cancer cells.
  • These findings suggest that targeting the ZC3H13/ADGRA3 axis could offer a novel therapeutic strategy for treating papillary thyroid cancer.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477e294https://doi.org/10.1007/s12672-025-03482-3
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Also Consider

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  3. 3[Mechanism of piR-hsa-26925 in regulating invasion and metastasis of lung adenocarcinoma via METTL3-mediated m6A methylation modification].2025
  4. 4APOBEC3C Suppresses Prostate Cancer by Regulating Key Molecules Involved in Cellular Inflammation, Cell Cycle Arrest, and DNA Damage Response2026 · 1 citations
  5. 5METTL3-mediated m 6 A modification promotes intervertebral disc degeneration2025 · 2 citations