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August 7, 2025Frontiers in ImmunologyOpen Access

The impact of enteral immunonutrition on gut microbiota in colorectal cancer and gastric cancer patients in the preoperative period—preliminary results of randomized clinical trial

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Authors

KKKarolina Kaźmierczak-SiedleckaESEwa StachowskaRKRobert Kucharski

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Overview

Randomized clinical trial showed no significant changes in gut microbiota of colorectal and gastric cancer patients, suggesting limited effects of immunonutrition.

Key Points

  • MAIN FINDING: Immunonutrition did not significantly alter gut microbiota in colorectal and gastric cancer patients before surgery.
  • KEY EVIDENCE: Statistical analysis showed no significant differences in alpha diversity indices between dietary groups.
  • APPROACH: Fourteen patients received either immunonutrition or standard products for seven days before surgery.
  • SIGNIFICANCE: Understanding immunonutrition's role in gut microbiota may inform nutritional support in cancer care.

Cite This Study

Kaźmierczak-Siedlecka et al. (2025) studied this question.

synapsesocial.com/papers/689dfe88d61984b91e13b7fehttps://doi.org/10.3389/fimmu.2025.1606187
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Perioperative Oral Immunonutrient Regulation of Intestinal Barrier and Gut Microbiota in Patients with Gastric Cancer, a Randomized Controlled Clinical Trial2025
  2. 2Effects of preoperative immunonutrition 2025
  3. 3Integrated Public Health Evaluation of Gut Microbiota, Inflammatory Biomarkers, and Nutritional Status in Patients Undergoing Colorectal Cancer Surgery2023
  4. 4Perioperative Immunonutrition in Gastrointestinal Oncology: A Comprehensive Umbrella Review and Meta-Analysis on Behalf of TROGSS—The Robotic Global Surgical Society2025
  5. 5Dietary Patterns and Gut Microbiome Modulation in Cancer Immunotherapy: A Systematic Review and Meta-Analysis2025