Perioperative Oral Immunonutrient Regulation of Intestinal Barrier and Gut Microbiota in Patients with Gastric Cancer, a Randomized Controlled Clinical Trial
Randomized controlled trial shows immunonutrients enhance intestinal barrier and gut microbiota in gastric cancer patients, indicating potential therapeutic benefits.
Key Points
Immunonutrients may attenuate surgery-induced intestinal barrier damage in gastric cancer patients, enhancing microbiota diversity.
The immunonutrients group showed significantly lower postoperative diamine oxidase and endotoxin levels, indicating improved intestinal barrier function.
Patients receiving immunonutrients exhibited changes in gut microbiota, with an increase in beneficial genera like Akkermansia and Bifidobacterium longum.
Functional pathway analysis suggested that immunonutrients play a role in enriching beneficial taxa and suppressing pathogenic bacteria.