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August 7, 2025Frontiers in ImmunologyOpen Access

Targeting macrophage phenotypes to prevent diseases caused by Leishmania and Trypanosoma cruzi infections

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Authors

NVNatália S. VellozoTMThayane C. Matos-SilvaMLMarcela F. Lopes

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Overview

This review discusses immunomodulation of macrophage phenotypes to prevent inflammatory diseases in Leishmania and Trypanosoma cruzi infections, suggesting novel therapeutic strategies.

Key Points

  • Main finding: Modulating macrophage phenotypes can prevent chronic infections caused by Leishmania and Trypanosoma cruzi.
  • Key evidence: Strategies include inducing M1 proinflammatory responses and inhibiting M2 pro-infection responses.
  • Approach: Experimental models tested pharmacological methods to influence macrophage activation during protozoan infections.
  • Significance: Understanding macrophage roles could lead to new treatments for inflammatory diseases linked to protozoan infections.

Cite This Study

Vellozo et al. (2025) studied this question.

synapsesocial.com/papers/689dfe9fd61984b91e13c4aehttps://doi.org/10.3389/fimmu.2025.1595954
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Macrophages in chronic infections: regulation and remodeling2025
  2. 2Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics2025 · 74 citations
  3. 3Trypanosoma Cruzi Lineages Shape Macrophage Cytokine Profiles in Single and Mixed Infections.2025
  4. 4Transcriptome profiling of L. infantum-infected human macrophages reveals sex-specific type I interferon induction.2025 · 5 citations
  5. 5Immunological characteristics and functions of macrophages in Mycobacterium leprae infection2025