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September 25, 2025Frontiers in ImmunologyOpen Access

Ontogeny specification and epigenetic regulation of macrophage plasticity

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Authors

HHHan-Ying HuangXZXin-Nan ZhengLTLin Tian

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Overview

This mini-review examines how ontogeny and epigenetic factors influence macrophage plasticity, highlighting their roles in disease.

Key Points

  • A deeper understanding of macrophage plasticity reveals essential regulatory mechanisms relevant to disease processes.
  • Recent advances in lineage tracing and multi-omic profiling unveil critical insights into macrophage differentiation and function.
  • New techniques for in situ profiling enable the study of macrophages in their native tissue environments, offering fresh perspectives.
  • Macrophage plasticity intersects with ontogeny and epigenetic regulation, suggesting novel therapeutic targets for treatment.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd6edc445aa9033b09e7https://doi.org/10.3389/fimmu.2025.1676953
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