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August 1, 2025Open Access

Changes in Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Their Relationship with Kidney Function in Different Stages of Chronic Kidney Disease

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Authors

BIBorislav IgnatovKKKrasimir KostovTETsvetelina Eftimova

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Overview

This study finds elevated NGAL levels correlated with kidney function decline in CKD patients, suggesting its potential as an important biomarker.

Key Points

  • NGAL levels rise significantly as chronic kidney disease progresses, reflecting worsening kidney function.
  • There is a strong correlation between increased NGAL levels and lower estimated glomerular filtration rate (eGFR).
  • Patients were categorized into three CKD groups based on eGFR levels for thorough analysis of NGAL.
  • Using NGAL as a biomarker could enhance existing diagnosis and monitoring methods for chronic kidney disease.

Cite This Study

Ignatov et al. (2025) studied this question.

synapsesocial.com/papers/689a0c65e6551bb0af8cfadbhttps://doi.org/10.20944/preprints202507.2290.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of neutrophil gelatinase-associated lipocalin (NGAL) levels as a biomarker for the early diagnosis of heart failure patients without of kidney disease2025
  2. 2Evaluating the Association Between Neutrophil Gelatinase‐Associated Lipocalin Levels and Periodontal Health Status in Patients With Chronic Kidney Disease2025 · 2 citations
  3. 3Assessing neutrophil gelatinase-associated lipocalin as an early indicator for AKI among gastroenteritis patients with dehydration2025
  4. 4Diagnostic utility of urinary neutrophil gelatinase associated lipocalin (µNGAL) in predicting the severity of acute kidney injury2025 · 1 citations
  5. 5Early Prediction of Post-Cardiac-Surgery Acute Kidney Injury: Urinary NGAL versus Serum Creatinine2025