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October 12, 2025Frontiers in Bioscience-ScholarOpen Access

Molecular Basis of Oxidative Stress-Induced Acute Kidney Injury, Kidney Fibrosis, Chronic Kidney Disease, and Clinical Significance of Targeting Reactive Oxygen Species-Regulated Pathways to Treat Kidney Disease

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Authors

RKRamji KandelPRPriti RoyKSKamaleshwar P. Singh

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Overview

Review highlights the role of oxidative stress in kidney damage, suggesting targeted therapies may improve chronic kidney disease outcomes.

Key Points

  • Targeting oxidative stress may improve outcomes in chronic kidney disease, especially post-acute kidney injury.
  • Oxidative stress is implicated in the transition from acute kidney injury to chronic kidney disease, affecting key signaling pathways.
  • Understanding the molecular mechanisms involved in kidney fibrosis is crucial for developing effective treatments for renal diseases.
  • Current therapies are ineffective for managing kidney fibrosis, highlighting the need for new strategies focusing on oxidative stress.

Cite This Study

Kandel et al. (2025) studied this question.

synapsesocial.com/papers/68ec1be02b8fa9b2b78ad32bhttps://doi.org/10.31083/fbs38963
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitophagy and oxidative stress in chronic kidney disease (Review)2025
  2. 2Protecting kidney function: from mechanisms to therapeutic targets and traditional Chinese medicine2025 · 5 citations
  3. 3Mechanisms of antioxidative and anti-inflammatory treatments in chronic kidney disease and the potential benefits of hydrogen therapy: A narrative review2025
  4. 4Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions2026 · 2 citations
  5. 5Mitochondrial dysfunction and metabolic reprogramming in acute kidney injury: mechanisms, therapeutic advances, and clinical challenges2025