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September 10, 2025Frontiers in OncologyOpen Access

The pivotal role of TGF-β/Smad pathway in fibrosis pathogenesis and treatment

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Authors

FCFeilong ChenLLLei LyuCXChengyuan Xing

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Overview

This analysis reveals TGF-β signaling's impact on fibrosis in various organs, suggesting targeted therapies.

Key Points

  • TGF-β signaling is central to fibrogenesis across multiple organ systems, impacting fibroblast activity.
  • Dysregulated TGF-β/Smad pathways lead to excessive extracellular matrix production, particularly collagen.
  • The study highlights the role of epithelial–mesenchymal transition as a major process in fibrosis development.
  • Future research aims to develop combinatorial antifibrotic strategies by understanding organ-specific pathways.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64784578https://doi.org/10.3389/fonc.2025.1649179
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SMAD7: riding on fibrosis-limiting routes and beyond2025
  2. 2Pathogenesis of Fibrosis: A Comprehensive Review of Oxidative, Inflammatory, and Immune Mechanisms Underlying Tissue Damage in Multiple Organ Systems2025
  3. 3Role of the TGF‑β/Smad signaling pathway in the transition from acute kidney injury to chronic kidney disease (Review)2025
  4. 4TGF-β-Driven Atrial Fibrosis in Atrial Fibrillation: From Mechanistic Insights to Targeted Therapies2025 · 4 citations
  5. 5TGF-β Signaling in Cancer: Mechanisms of Progression and Therapeutic Targets2025