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July 28, 2025

The longitudinal associations of selected Tubular Biomarkers Predict the Risk of Nephropathy Progression in Diabetic Patients: systematic review and meta-analysis

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Authors

SSSaba ShafieizadeganPYParvin YavariMYMaryam Yazdi

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Overview

Systematic review demonstrates that tubular biomarkers predict diabetic nephropathy progression in patients, suggesting improved patient management.

Key Points

  • Elevated serum KIM-1 levels (RR=1.68) are significantly associated with diabetic nephropathy progression.
  • Urinary biomarkers, especially KIM-1 and LFABP, show higher relative risks for predicting early progression of diabetic nephropathy.
  • The analysis included 31 studies with 29,818 patients focusing on tubular biomarkers and diabetic nephropathy outcomes.
  • Findings indicate that using tubular biomarkers may lead to earlier diagnosis and better management of diabetic nephropathy.

Cite This Study

Shafieizadegan et al. (2025) studied this question.

synapsesocial.com/papers/689a0939e6551bb0af8ce908https://doi.org/10.21203/rs.3.rs-7008420/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of novel biomarkers urinary NGAL and MCP-1 in predicting progression of diabetic kidney disease in type 2 DM2025
  2. 2Predictive value of biomarkers for tubulointerstitial and glomerular interactions in diabetic nephropathy2025
  3. 3Kidney Tubular Biomarkers Predict Risk of Death and Heart Failure Readmission in Acute Heart Failure2025 · 4 citations
  4. 4Associations of Biomarkers of Kidney Tubule Health with Retinal Microvascular Signs2025
  5. 5Changes in Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Their Relationship with Kidney Function in Different Stages of Chronic Kidney Disease2025