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October 2, 2025Renal FailureOpen Access

Role of novel biomarkers urinary NGAL and MCP-1 in predicting progression of diabetic kidney disease in type 2 DM

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Authors

SSShilna Muttickal SwaminathanMBMohan V BhojarajaIRIndu Ramachandra Rao

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Overview

Prospective observational study identifies urinary NGAL and MCP-1 as key predictors of rapid diabetic kidney disease progression in type 2 diabetes.

Key Points

  • Rapid progression of diabetic kidney disease affects about 38.6% of patients with type 2 diabetes during a median follow-up of 1.3 years.
  • Median levels of urinary biomarkers NGAL and MCP-1 were significantly higher in rapid progressors, showing diagnostic accuracy in predicting disease progression.
  • Multivariate analysis revealed urinary NGAL, MCP-1, and albumin-to-creatinine ratio as independent risk factors for rapid progression of diabetic kidney disease.
  • A combined panel of urinary biomarkers improved predictability for identifying rapid progressors, suggesting potential for noninvasive monitoring.

Cite This Study

Swaminathan et al. (2025) studied this question.

synapsesocial.com/papers/68de84c45b556a9128e1c1a9https://doi.org/10.1080/0886022x.2025.2563671
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessment and prediction of diabetic kidney disease in patients with type 2 diabetes mellitus by using an advanced biomarkers2025
  2. 2Changes in Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Their Relationship with Kidney Function in Different Stages of Chronic Kidney Disease2025
  3. 3The longitudinal associations of selected Tubular Biomarkers Predict the Risk of Nephropathy Progression in Diabetic Patients: systematic review and meta-analysis2025 · 1 citations
  4. 4Diagnostic utility of urinary neutrophil gelatinase associated lipocalin (µNGAL) in predicting the severity of acute kidney injury2025
  5. 5<b>Dickkopf-3 (DKK3) </b><b>and the progression of diabetic kidney disease</b><b>in primary health care</b>2025