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September 10, 2025Journal of the American Heart AssociationOpen Access

Kidney Tubular Biomarkers Predict Risk of Death and Heart Failure Readmission in Acute Heart Failure

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Authors

NWNicholas WetterstenSDStephen DuffYHYu Horiuchi

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Overview

Observational analysis links kidney tubular biomarkers to increased death and HF readmission risk in patients, indicating their clinical relevance.

Key Points

  • Each 2-fold increase in IGFBP-7 correlates with a 36% heightened risk of death or heart failure readmission.
  • A total of 156 deaths or HF readmissions were recorded over one year in the assessed population of 436 individuals.
  • Urine biomarkers of kidney tubular damage were measured during hospital admission for acute heart failure patients.
  • Findings suggest a strong relationship between kidney tubular health and adverse outcomes, independent of glomerular function.

Cite This Study

Wettersten et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478a3e7https://doi.org/10.1161/jaha.125.042880
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