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January 9, 2026World Journal of NephrologyOpen Access

Predictive value of biomarkers for tubulointerstitial and glomerular interactions in diabetic nephropathy

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Key result

Increased periostin, neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1 levels are valuable biomarkers for assessing tubular damage in diabetic nephropathy.

Authors

MAMario Alamilla-SanchezMEMartin B Yama EstrellaELEnrique F Morales López

Discussion

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Overview

Commentary highlights biomarkers predicting tubular and glomerular damage in diabetic nephropathy, suggesting clinical implications.

Key Points

  • Explore how biomarkers aid in assessing tubulointerstitial and glomerular interactions in diabetic nephropathy.
  • Review of Varatharajan et al.'s findings on tubulointerstitial damage in diabetic nephropathy.
  • Discussion on the interaction between interstitium, tubules, and glomeruli.
  • Analysis of periostin and other biomarkers in tissue, serum, and urine.
  • Increased periostin levels correlate with type 2 diabetes and tubulointerstitial damage.
  • Neutrophil gelatinase-associated lipocalin indicates distal tubular injury.
  • Kidney injury molecule-1 serves as a marker for proximal tubular damage.
  • Combining these biomarkers improves diagnostic accuracy.

Cite This Study

Alamilla-Sanchez et al. (2025) studied this question. Increased periostin, neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1 levels are valuable biomarkers for assessing tubular damage in diabetic nephropathy.

synapsesocial.com/papers/696128f644c2cd6c68456ca7https://doi.org/10.5527/wjn.v14.i4.103649
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The longitudinal associations of selected Tubular Biomarkers Predict the Risk of Nephropathy Progression in Diabetic Patients: systematic review and meta-analysis2025 · 1 citations
  2. 2Comprehensive bioinformatics and in vivo validation reveal key molecular drivers of diabetic nephropathy progression2025 · 2 citations
  3. 3Associations of Biomarkers of Kidney Tubule Health with Retinal Microvascular Signs2025
  4. 4The Emerging Role of Integrins in Diabetic Kidney Disease: A Systematic Review and Meta-Analysis of Their Diagnostic and Prognostic Utility for Early Risk Stratification2025
  5. 5Exploring the Proteomic Signature of Diabetic Nephropathy: Implications for Early Diagnosis and Treatment2025 · 4 citations