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July 24, 2025Journal of Geriatric Psychiatry and Neurology

Targeting Inflammation in Alzheimer’s Disease: Insights Into Pathophysiology and Therapeutic Avenues-A Comprehensive Review

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Authors

VTVasileios TopalisCVCharalampos VorosMZMairi Ziaka

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Overview

Comprehensive review highlights neuroinflammation's role in cognitive decline and potential therapeutic avenues in Alzheimer's disease.

Key Points

  • Alzheimer's disease is characterized by cognitive decline, including memory and executive function deficits, primarily affecting adults over 65.
  • Neuroinflammation plays a critical role in AD, with altered microglial responses linked to increased Aβ risk and neuronal damage.
  • Astrocytes contribute to neuroprotection, but Aβ can induce reactivity leading to toxic effects and impaired Aβ clearance.
  • Current therapeutic approaches focus on slowing AD progression through targeting amyloid-beta and tau, with a growing emphasis on addressing neuroinflammation.

Cite This Study

Topalis et al. (2025) studied this question.

synapsesocial.com/papers/689a0621e6551bb0af8cdf07https://doi.org/10.1177/08919887251361578
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms2025
  2. 2Targeting glial dysfunction in Alzheimer’s disease: insights into pathogenesis and emerging therapeutics2025 · 4 citations
  3. 3Microglial Neuroinflammation in Alzheimer’s Disease: Mechanisms and Therapies2025 · 11 citations
  4. 4Pathological mechanisms and treatment progression of Alzheimer’s disease2025 · 72 citations
  5. 5Neurodegeneration in Alzheimer’s disease: A narrative review of mechanistic insights and emerging therapeutic approaches2025 · 1 citations