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September 5, 2025Advanced NeurologyOpen Access

Neurodegeneration in Alzheimer’s disease: A narrative review of mechanistic insights and emerging therapeutic approaches

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Authors

MHMd. Nazmul HossainRBRabeya Sultana BadhonMBMohammad Shahangir Biswas

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Overview

Literature review highlights mechanisms like beta-amyloid aggregation in Alzheimer's disease, suggesting new therapeutic approaches.

Key Points

  • Alzheimer's disease impacts cognitive functions, memory, and behavior, primarily affecting older adults.
  • Major pathogenic mechanisms include β-amyloid aggregation and tau protein hyperphosphorylation that underlie neurodegeneration.
  • Comprehensive literature review analyzed recent advancements in diagnostics and novel therapeutic approaches for Alzheimer's disease.
  • Despite research progress, effective disease-modifying therapies in Alzheimer's remain elusive, emphasizing the need for ongoing biomarker discovery.

Cite This Study

Hossain et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477c3cfhttps://doi.org/10.36922/an025160040
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