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September 12, 2025Ageing and Neurodegenerative DiseasesOpen Access

Targeting glial dysfunction in Alzheimer’s disease: insights into pathogenesis and emerging therapeutics

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Authors

QZQing ZhuThe Wistar InstituteYSYu SongCity University of Hong KongYQYuanyuan QianZhejiang Chinese Medical University

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Implication

This review uncovers the role of glial cells in alzheimer's disease pathogenesis and highlights emerging therapeutics.

Key Points

  • Targeting glial cells may offer new therapeutic avenues for alzheimer's disease, improving outcomes for patients.
  • Key pathways, including NF-κB and NLRP3 inflammasome, illustrate how glial dysfunction impacts disease progression.
  • Emerging therapies focus on restoring glial homeostasis, which could mitigate neuroinflammation and enhance cognition.
  • Future research must address translational challenges in harnessing glial biology for effective alzheimer's disease therapies.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68d41ed2713b0b5dfea678a2https://doi.org/10.20517/and.2025.25
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